Hypertrophic olivary degeneration: the forgotten triangle of Guillain and Mollaret.

developed the neurological events while on treatment. CNS in volvement in Choriocarcinoma can be due to hemorrhagic metastas, tumor embolization and chemotherapy (especially platinum compounds). CNS thrombotic events are extremely rare. The association between cancer and thrombosis was identified in 1865 and the combination is called as Trousseau syndrome.[2] The mechanisms elucidated include cytokines like TNFa, IL-1, and IL-6 that cause endothelial damage resulting in thrombosis.[3] The interaction between tumor cells and macrophages activates platelets and factors XII and X, which leads to thrombin generation and thrombosis. The various chemotherapeutic agents including platinum compounds can cause endothelial damage. Central venous catheters and total parenteral nutrition also increase the risk.